Halloween Patterns
Steroid hormones control many aspects of reproduction, development, and homeostasis in higher organisms. In arthropods, steroid hormones play equal or even more vital developmental roles, especially in controlling the patterns of gene expression between developmental stages.
The spook gene (Cyp307a1) is expressed in the prothoracic gland, and in conjunction with the gene product of spookier (Cyp307a2), converts 7-dehydrocholesterol to Δ4-diketol.
The phantom gene (Cyp306a1) encodes a encoding the microsomal 25-hydroxylase. Strong expression of phm is restricted to the prothoracic gland cells of the Drosophila larval ring gland. The gene product converts 2,22,25dE-ketodiol to 2,22dE-ketotriol.
The disembodied gene (Cyp302a1) codes for a cytochrome P450 enzyme that adds a hydroxyl group to the carbon-22 position of 2,22,dE-ketotriol to make 2-deoxyecdysone. dib mutants are defective in producing their cuticle and have severe defects in morphological processes such as head involution, dorsal closure and gut development.
The shade gene (Cyp314a1) codes for a P450 enzyme responsible for adding a hydroxyl group to the 2C-position of ecdysone to make 20-hydroxyecdysone, the final step in the biosynthetic pathway.
The spook gene (Cyp307a1) is expressed in the prothoracic gland, and in conjunction with the gene product of spookier (Cyp307a2), converts 7-dehydrocholesterol to Δ4-diketol.
The phantom gene (Cyp306a1) encodes a encoding the microsomal 25-hydroxylase. Strong expression of phm is restricted to the prothoracic gland cells of the Drosophila larval ring gland. The gene product converts 2,22,25dE-ketodiol to 2,22dE-ketotriol.
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